NeuroNexus now produces cuff electrodes that provide all of the functionality of a standard cuff, but with some extra features found only in our products.
- Our cuffs are polyimide-based, similar to our E-probes, which makes them very thin, soft, and flexible. This makes the cuff/nerve interface gentler and easier to fit/conform than some of the bulkier silicone cuffs.
- Cuff sites can be placed in numbers, designs, and concentrations to allow more focused and/or articulate streams of current. For example, instead of a dipole site arrangement with two large sites, several smaller sites can be used to build a dipole-like stim arrangement but with more controlled current-flow properties.
- Customization is an option. Just like standard NeuroNexus probes, there will be a series of standard cuff designs available in the catalog. You will also be able to draw up a design that fits your needs and send it to us so we can fabricate it for you.
We utilized one of our early cuff designs in an extramural lab visit to UCLA. This was one of our larger cuff designs, to be placed on the vagal nerve of a pig. The purpose was vagal nerve stimulation which would lead to bradycardia, reduced contractility, lowering of left ventricular systolic pressure and lengthening of activation recover intervals. Here is an image of some of these parameters being measured, during our experiment:
Our collaborator reviews of the cuff we used that day were very positive. Among the notable responses:
"The cuff was very easy to place, and didn't torque the nerve at all."
"The cuff conformed well to the nerve, with a secure interface."
"The stimulation current levels required to evoke a response are startlingly low." The PI was most excited about this development, and this was the feature that made him most likely to develop an experiment designed specifically around the use of NeuroNexus cuffs.
In summary, NeuroNexus has our own version of the cuff electrode available for use. These cuffs can be optimized for use in small or large animals, have physical properties that make them more conducive for minimal interference and maximal interface with the nerve, and offers creative site arrangements to increase current focus and articulation. As a result, in this experiment, effects were observed at much lower currents than usual, allowing for more efficient current usage with other possible positive effects (e.g. less current leakage, less potential side effect, possibly higher resolution for observing effects, etc.).
Close-up detail, Insertion methods, and more
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