This paper evaluates aberrant brain neurophysiology, specifically focal cortical dysplacias (FCDs), which are common causes of brain seizures and often associated with intractable epilepsy. FCD was induced in a mouse model by neonatal freeze lesions (FLs) near the primary somatosensory cortex (S1). Linear multi-electrode arrays were used to record near the FL. Results indicated that FL animals exhibit a high prevalence of spontaneous spike-wave discharges, predominantly during sleep, and an increase in the incidence of hyper-excitable burst/suppression activity under general anesthesia. The paper concludes that monitoring the altered electrophysiology of burst activity under general anesthesia with multi-dimensional micro-electrode arrays may serve to define distinct neurophysiological biomarkers of epileptogenesis in human brain and improve techniques for surgical resection of epileptogenic malformed brain tissue.
Visit our YouTube playlist to learn more about hardware setup, recording with the SmartBox, and more.
Trial the SmartBox™ in your own lab.
On the Blog:
The SmartBox 2.0 software integrates probe mapping into the recording user interface, providing extremely convenient spike identification during recording.