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Jan2017 SUImage

Enhanced Burst-Suppression and Disruption of Local Field Potential Synchrony in a Mouse Model of Focal Cortical Dysplasia Exhibiting Spike-Wave Seizures

1ST AUTHOR: Anthony J. Williams

LAST AUTHOR: Qian-Quan Sun

ANIMAL MODEL: Mouse, focal cortical dysplasias

EXPERIMENT: Acute, Epilepsy/Seizure focus

PROBE TYPE: SmartBox Data Acquisition system, Penetrating electrode arrays

This paper evaluates aberrant brain neurophysiology, specifically focal cortical dysplasias (FCDs), which are common causes of brain seizures and often associated with intractable epilepsy. FCD was induced in a mouse model by neonatal freeze lesions (FLs) near the primary somatosensory cortex (S1). Linear multi-electrode arrays were used to record near the FL. Results indicated that FL animals exhibit a high prevalence of spontaneous spike-wave discharges, predominantly during sleep, and an increase in the incidence of hyper-excitable burst/suppression activity under general anesthesia. The paper concludes that monitoring the altered electrophysiology of burst activity under general anesthesia with multi-dimensional micro-electrode arrays may serve to define distinct neurophysiological biomarkers of epileptogenesis in human brain and improve techniques for surgical resection of epileptogenic malformed brain tissue.


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