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Science Update

Spatial Mapping in the Rat Olfactory Bulb by Odor and Direct Electrical Stimulation

Publication Details

Featured Authors

Daniel H. Coelho

Richard M. Costanzo

Journal Name
Otolaryngology Head Neck Surg.
Experiment Type
Acute
Animal Model
Rat
Brain Region
Olfactory Bulb
Brain Signal
Multi Unit
Brain Signal
LFP
Product Category
  • SmartBox
  • Penetrating Electrode
Product
  • A4x8-5mm-100-400-703
Probe Detail/Package
A32, SmartBox
Abstract
Objectives. To directly measure the spatial mapping in the olfactory bulb by odor presentation and by direct electrical stimulation. Study Design. Experimental (animal). Setting. University research laboratory. Subjects and Methods. Odor (n = 8) and electrical stimulation (n = 4) of the olfactory bulb in rats were used to demonstrate the spatial mapping of neural responses in the olfactory bulb. Both multiunit responses to odor stimulation and evoked potential responses to localized electrical stimulation were measured in different regions of the olfactory bulb. Results. Responses that were recorded simultaneously from an array of 32 electrodes positioned at different locations within the olfactory bulb were mapped. Results show different spatial patterns of neural activity for different odors (odor maps). Direct stimulation of the olfactory bulb with electrical current pulses from electrodes positioned at different locations was also effective in generating spatial patterns of neural activity. Conclusion. These data suggest that by programming an array of stimulating electrodes, it should be possible to selectively activate different regions of the olfactory bulb, generating unique patterns of neural activity as seen in normal smell.
Citation
Coelho et al. "Spatial Mapping in the Rat Olfactory Bulb by Odor and Direct Electrical Stimulation." Otolaryngology - Head and Neck Surgery, Vol 155 (3) pp. 526 - 532. DOI: 10.1177/0194599816646358
Publication Date
04/ 5/2016
Country
United States
Institution
Virginia Commonwealth University