Multi-Unit Activity contains information about spatial stimulus structure in mouse primary visual cortex

By August 1, 2015

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Marie Tolkiehn Simon R. Schultz
Acute Mouse Cortex Visual Penetrating Electrode A4x8-5mm-100-200-177

This study investigates the spatial and directional tuning of Multi-Unit Activity (MUA) in mouse primary visual cortex and how MUA can reflect spatiotemporal structures contained in moving gratings. Analysis of multi-shank laminar electrophysiological recordings from mouse primary visualcortex indicates a directional preference for moving gratings around 180°, while preferred spatial frequency peaks around 0.02 cycles per degree, which is similar as reported in single-unit studies. Using only features from MUA, we further achieved a significant performance in decoding spatialfrequency or direction of moving gratings, with average decoding performances of up to 58.54% for 8 directions, and 44% correctly identified spatialfrequencies against chance level of 16.7%.

Conf Proc IEEE Eng Med Biol Soc. 2015 Aug;2015:3771-4. doi: 10.1109/EMBC.2015.7319214. August 1, 2015 Imperial College London