Tail-clamping stimulation increases phase-locking neurons in the hippocampus of anaesthetized rat

By June 4, 2014

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Y. Wang Z.Y. Feng
Acute Rat Hippocampus LFP Penetrating Electrode

Phase-locking is an important encoding mode in the hippocampal region of brain where neuronal firing concentrates on a certain phase of the periodic field potential, especially θ rhythm. It can be observed during many behaviors while the locked-phase varies accordingly. In this study, the changes of neuronal phase-locking induced by somatosensory stimulation of tail-clamping were investigated. The local field potential and spike signals were recorded in hippocampal CA1 region of anesthetized rats with microelectrode array. The phase-locking relationship was analyzed with Raleigh test and spike-phase histogram. The results showed that during spontaneous activity, 3 of 20 examined neurons were phase-locking to the θ rhythm of the field potential. However, during the tail clamping periods, the number of phase-locking neurons increased from 3 to 8, and the mean locked-phase shifted towards the negative peak of the field potential cycle, which became θ rhythm dominated. These findings suggest that the hippocampus may encode somatosensory information with the phase-locking neurons and by shifting their locked-phases.

DOI:10.1109/BHI.2014.6864472

http://ieeexplore.ieee.org/xpl/login.jsp?tp=&arnumber=6864472&url=http%3A%2F%2Fieeexplore.ieee.org%2Fxpls%2Fabs_all.jsp%3Farnumber%3D6864472 June 4, 2014 Zhejiang University