Spatial Mapping in the Rat Olfactory Bulb by Odor and Direct Electrical Stimulation

By April 5, 2016

Publication Details

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Daniel H. Coelho Richard M. Costanzo
Otolaryngology Head Neck Surg. Acute Rat Olfactory Bulb LFP SmartBox|Penetrating Electrode A4x8-5mm-100-400-703 A32, SmartBox

Objectives. To directly measure the spatial mapping in the
olfactory bulb by odor presentation and by direct electrical
stimulation.

Study Design. Experimental (animal).

Setting. University research laboratory.

Subjects and Methods. Odor (n = 8) and electrical stimulation (n = 4) of the olfactory bulb in rats were used to demonstrate the spatial mapping of neural responses in the olfactory bulb. Both multiunit responses to odor stimulation and evoked potential responses to localized electrical stimulation were measured in different regions of the olfactory bulb.

Results. Responses that were recorded simultaneously from
an array of 32 electrodes positioned at different locations
within the olfactory bulb were mapped. Results show different spatial patterns of neural activity for different odors (odor maps). Direct stimulation of the olfactory bulb with electrical current pulses from electrodes positioned at different locations was also effective in generating spatial patterns of neural activity.

Conclusion. These data suggest that by programming an array
of stimulating electrodes, it should be possible to selectively activate different regions of the olfactory bulb, generating unique patterns of neural activity as seen in normal smell.

Coelho et al. "Spatial Mapping in the Rat Olfactory Bulb by Odor and Direct Electrical Stimulation." Otolaryngology - Head and Neck Surgery, Vol 155 (3) pp. 526 - 532. DOI: 10.1177/0194599816646358

http://journals.sagepub.com/doi/pdf/10.1177/0194599816646358 April 5, 2016 Virginia Commonwealth University